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Lipid peroxidation, GSH depletion, and SLC7A11 inhibition are common causes of EMT and ferroptosis in A549 cells, but different in specific mechanisms

GSH exists in cells mostly in the reduced form (GSH) which is constantly oxidized forming oxidized GSH and its supply is replenished by the action of GSH reductase

Oxidative stress occurs when there is an imbalance of free radicals and antioxidants, while reductive stress occurs when there are too many antioxidants

rather, rhamnetin seems to exert cardioprotective effects, especially under oxidative stress